T cells with cell surface expression of adenosine deaminase and uses thereof

• Main Authors: KRETZ DANIEL D, MCCALL CHRISTOPHER L
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure generally relates to compositions and methods for robust improvement of fitness and function of CAR T cells. More specifically, the present disclosure relates to novel chimeric polypeptides capable of anchoring adenosine deaminase activity to the surface of a T cell, nucleic acids encoding the chimeric polypeptides, engineered T cells comprising the chimeric polypeptides or nucleic acids encoding the chimeric polypeptides. Also provided herein are methods of producing the engineered T cells, methods of administering the engineered T cells, and methods of treating an individual having a related health condition. 本公开文本总体上涉及用于稳健地改善CAR T细胞的适合度和功能的组合物和方法。更具体地，本公开文本涉及能够将腺苷脱氨酶活性锚定至T细胞表面的新型嵌合多肽、编码所述嵌合多肽的核酸、包含所述嵌合多肽或编码所述嵌合多肽的核酸的工程化T细胞。本文还提供了产生所述工程化T细胞的方法、施用所述工程化T细胞的方法和治疗具有相关健康情况的个体的方法。