Compositions for post-injury cartilage regeneration and regrowth methods

• Main Authors: HOLSWORTH, DAVID, SARASWATI SURESH
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a method of enhancing cartilage regeneration after injury in a mammal comprising identifying a mammal that is experiencing cartilage injury, administering to the mammal a composition comprising covalently linked graphene oxide (GO) with hyaluronic acid (HA), XAV939, and water. The composition of the method may also include a surfactant, such as PEG. The composition may be topically administered to a subject to treat cartilage injury in the subject. 本发明提供了在哺乳动物受伤后增强软骨再生的方法，其包括：识别其正在经历软骨损伤的哺乳动物，向所述哺乳动物施用包含共价连接的氧化石墨烯(GO)与透明质酸(HA)、XAV939、和水的组合物。所述方法的组合物还可包括表面活性剂，例如PEG。所述组合物可局部施用于受试者以治疗所述受试者的软骨损伤。