Nanometer antibody screening method and device, chip and terminal

• Main Authors: HUANG BINGDING, WANG XIN, LIANG LIXIN, QIN WEI, MEI FENGCHENG, LI NING, LEI GAOMING
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2024
• Subjects: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

The embodiment of the invention discloses a nano-antibody screening method and device, a chip and a terminal.The nano-antibody screening method comprises the steps that different types of nano-antibody data are obtained from a plurality of publicly accessible bioinformatics databases, integration and standardization processing are conducted on the nano-antibody data, and nano-antibody sequence entries are obtained; determining a target virus, and retrieving a protein structure file of a nano antibody compound related to the target virus from the protein structure database; and screening out a target nano antibody matched with the protein structure file from the nano antibody sequence entries by utilizing molecular docking and biological interaction. The problem that an existing nano antibody is low in screening accuracy is solved. 本发明实施例公开了一种纳米抗体筛选方法、装置、芯片及终端，通过从多个可公开访问的生物信息学数据库中获取不同类型的纳米抗体数据，并对各纳米抗体数据进行整合和标准化处理，得到纳米抗体序列条目；确定目标病毒，并从蛋白质结构数据库中检索到与目标病毒相关的纳米抗体复合物的蛋白质结构文件；利用分子对接和生物相互作用，从纳米抗体序列条目中筛选出与蛋白质结构文件匹配的目标纳米