Recombinant protein vaccine and application thereof
The invention provides a novel coronavirus recombinant spike (S) protein or a fragment thereof, which is characterized in that the recombinant S protein or the fragment thereof comprises a first structural domain from an N terminal to a C terminal, the first structural domain comprises an amino acid...
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Main Authors | , , , , , , , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
18.06.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The invention provides a novel coronavirus recombinant spike (S) protein or a fragment thereof, which is characterized in that the recombinant S protein or the fragment thereof comprises a first structural domain from an N terminal to a C terminal, the first structural domain comprises an amino acid sequence as shown in SEQ ID NO: 1, or an amino acid sequence having at least 85% sequence identity with the amino acid sequence as shown in SEQ ID NO: 1, and a second structural domain comprising an amino acid sequence as shown in SEQ ID NO: 2, or an amino acid sequence having at least 85% sequence identity with the amino acid sequence as shown in SEQ ID NO: 3; and, a second structural domain, the second structural domain being a trimerization structural domain. The invention also discloses a nucleic acid molecule for coding the recombinant S protein or the fragment thereof, a vaccine composition containing the recombinant S protein or the fragment thereof, and application of the recombinant S protein or the fragm |
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Bibliography: | Application Number: CN202211620739 |