Recombinant protein vaccine and application thereof

• Main Authors: JIANG LU, ZHOU CHUAN, GAO QIANG, ZHAI ZHENHUA, YIN WEIDONG, CUI GUOLIANG, YAN HAOHAO, WANG XIANGXI, LI FA, LIU CHANGSHENG, HU YALING, LIAN XIAOJUAN, BAO PENG, CHENG HUIXIN
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides a novel coronavirus recombinant spike (S) protein or a fragment thereof, which is characterized in that the recombinant S protein or the fragment thereof comprises a first structural domain from an N terminal to a C terminal, the first structural domain comprises an amino acid sequence as shown in SEQ ID NO: 1, or an amino acid sequence having at least 85% sequence identity with the amino acid sequence as shown in SEQ ID NO: 1, and a second structural domain comprising an amino acid sequence as shown in SEQ ID NO: 2, or an amino acid sequence having at least 85% sequence identity with the amino acid sequence as shown in SEQ ID NO: 3; and, a second structural domain, the second structural domain being a trimerization structural domain. The invention also discloses a nucleic acid molecule for coding the recombinant S protein or the fragment thereof, a vaccine composition containing the recombinant S protein or the fragment thereof, and application of the recombinant S protein or the fragm