Heparin-like adsorbent as well as preparation method and application thereof

• Main Authors: CAO MENGWEI, NI QIANG, DONG FAN, LIU HU
• Format: Patent
• Language: Chinese; English
• Published: 18.06.2024
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention provides a heparinoid adsorbent and a preparation method and application thereof.The heparinoid adsorbent comprises an adsorbent carrier and a polymeric membrane layer, the adsorbent carrier is of a porous structure, the polymeric membrane layer wraps the surface of the adsorbent carrier, and a network of the polymeric membrane layer interpenetrates the adsorbent carrier; the polymeric membrane layer is formed by cross-linking acrylic acid and sodium allyloxy hydroxypropyl sulfonate. The polymeric membrane layer is rich in sulfonic acid groups and carboxyl groups, so that the polymeric membrane layer has a structure and functional groups similar to those of anticoagulant heparin molecules, the polymeric membrane layer has excellent anticoagulant performance, and the polymeric membrane layer is coated on the surface of the adsorbent carrier, so that the anticoagulant performance of the adsorbent carrier is improved; in the clinical use process, the heparin adsorbent is adopted, so that a better a