Structure and synthesis method of nanoscale carboxyphenylboronic acid esterified Res and BX quaternary grafted composite derivative

• Main Authors: QIAN JINGXIA, LIU HUAFENG, YANG JINWU, LYU YIJU, ZHENG GUANGLU, LIU JINJU, ZOU ZHIMING, TIAN KEXIN, YANG YINGYING, LI HEPING, LI MINGKUN
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2024
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses a synthesis method of a nanoscale carboxyphenylboronic acid esterified Res and BX quaternary grafted composite derivative. On the basis of simulating docking between a small molecule ligand and an oncoprotein receptor by adopting a molecular docking technology, screening and optimizing the small molecule ligand and selecting an optimized active monomer and organic acid, a BX/Res compound is used as a raw material, EGDMA, TBMA and SSS are used as grafting monomers, and a Res and BX quaternary composite grafted copolymer is synthesized through free radical polymerization; and further synthesizing a product carboxyphenylboronic acid esterified Res and BX quaternary grafted derivative in a dimethyl sulfoxide solvent by taking carboxyphenylboronic acid as an esterifying agent and 4-dimethylaminopyridine and 12-tungsten phosphoric acid as a composite catalyst. And then preparing the nanoscale carboxyl phenylboronic acid esterified Res and BX quaternary grafted composite derivative through a