Artemisia laevigata lactone I derivative, pharmaceutical composition thereof, preparation method and application of artemisia laevigata lactone I derivative

• Main Authors: LI TIANZE, MA YUNBAO, MA WENJING, CHEN JIJUN, WANG XING
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides 33 abelmoschus laevigatus lactone I derivatives 1-33 as shown in a structural formula (I) as well as a pharmaceutical composition, a preparation method and application thereof, and belongs to the technical field of medicines. The artemisia lavandulolactone I derivatives 1-33 provided by the invention have obvious inhibitory activity on human hepatoma cell lines (HepG2, Huh7 and SK-Hep-1), can form a pharmaceutical composition with a pharmaceutically acceptable carrier, and can be used for preparing anti-hepatoma drugs. 本发明提供结构式（I）所示33个野艾蒿内酯I衍生物1-33及其药物组合物和其制备方法与应用，属于药物技术领域。本发明的野艾蒿内酯I衍生物1-33对人肝癌细胞株(HepG2，Huh7,SK-Hep-1)具有明显的抑制活性，能够与可药用载体组成药物组合物，能够用于制备抗肝癌药物。