Artemisia laevigata lactone I derivative, pharmaceutical composition thereof, preparation method and application of artemisia laevigata lactone I derivative

The invention provides 33 abelmoschus laevigatus lactone I derivatives 1-33 as shown in a structural formula (I) as well as a pharmaceutical composition, a preparation method and application thereof, and belongs to the technical field of medicines. The artemisia lavandulolactone I derivatives 1-33 p...

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Bibliographic Details
Main Authors LI TIANZE, MA YUNBAO, MA WENJING, CHEN JIJUN, WANG XING
Format Patent
LanguageChinese
English
Published 14.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides 33 abelmoschus laevigatus lactone I derivatives 1-33 as shown in a structural formula (I) as well as a pharmaceutical composition, a preparation method and application thereof, and belongs to the technical field of medicines. The artemisia lavandulolactone I derivatives 1-33 provided by the invention have obvious inhibitory activity on human hepatoma cell lines (HepG2, Huh7 and SK-Hep-1), can form a pharmaceutical composition with a pharmaceutically acceptable carrier, and can be used for preparing anti-hepatoma drugs. 本发明提供结构式（I）所示33个野艾蒿内酯I衍生物1-33及其药物组合物和其制备方法与应用，属于药物技术领域。本发明的野艾蒿内酯I衍生物1-33对人肝癌细胞株(HepG2，Huh7,SK-Hep-1)具有明显的抑制活性，能够与可药用载体组成药物组合物，能够用于制备抗肝癌药物。
Bibliography:Application Number: CN202410295603