Application of ten-ingredient frankincense powder in prevention and treatment of kidney diseases

• Main Authors: BAIMA DANZENG, NIMACIREN, XIE HEBING, YUAN ZHIBING
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of traditional Chinese medicine, and particularly relates to application of ten-ingredient frankincense powder in prevention and treatment of kidney diseases. The ten-ingredient frankincense powder has the effects of reducing the content of ROS and MDA, improving the activity of SOD to play an antioxidant role, inhibiting expression of inflammatory factors IL-1beta and TNF-alpha and expression of pro-apoptosis genes Bax, Caspase-3 and Caspase-9 to play anti-inflammatory and anti-apoptosis roles and effectively preventing, treating and improving the renal injury condition, and the mechanism of the ten-ingredient frankincense powder is possibly related to mitochondrial autophagy activated by up-regulation of a Pink1/Parkin signal channel. 本发明中药领域，具体涉及一种十味乳香散在防治肾脏疾病中的用途。十味乳香散具有降低ROS、MDA含量，提高SOD活性发挥抗氧化作用，抑制炎症因子IL-1β、TNF-α和促凋亡基因Bax、Caspase-3、Caspase-9的表达发挥抗炎和抗细胞凋亡作用，有效预防和治疗改善肾损伤情况，其机制可能与上调Pink1/Parkin信号通路激活线粒体自噬有关。