Application of tSFTA3 in prevention and treatment of lung cancer

• Main Authors: ZHOU XIAORONG, DING XIAOLING, YU CHENCHEN
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of biology, and particularly discloses application of tSFTA3 in prevention and treatment of lung cancer. On one hand, the invention relates to application of tSFTA3 in preparation of drugs for preventing and treating lung adenocarcinoma and/or lung squamous carcinoma; on the other hand, the invention relates to application of tSFTA3 in preparation of products for enhancing the sensitivity of lung cancer cells to targeted drugs. The invention further relates to application of the tSFTA3 combined with at least one of trametinib, darafenib and sotoprasib in preparation of a product for preventing and treating lung cancer. The tSFTA3 gene has a protein coding function, and after the protein is expressed, the proliferation of a lung adenocarcinoma cell strain can be remarkably inhibited, the sensitivity of tumor cells to targeted therapeutic drugs can be enhanced, and the growth of tumors can be inhibited in animal experiments, so that the expression vector (such as pLV