Application of antisense oligonucleotide in preparation of medicine for treating diseases caused by thyroid abnormality

• Main Authors: SONG GENGSHEN, ZHOU YUTING
• Format: Patent
• Language: Chinese; English
• Published: 14.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of gene therapy of thyroid-associated ophthalmopathy, in particular to application of antisense oligonucleotide in preparation of drugs for treating diseases caused by thyroid abnormality. Experimental results show that the antisense oligonucleotide S-ASODN-1 with a specific sequence for the insulin-like growth factor-1 receptor IGF-1R can effectively reduce the concentration of the IGF-1R and the concentration of an anti-thyroid peroxidase antibody (TPO-Ab) and improve the level of thyroid stimulating hormone (TSH), and the antisense oligonucleotide S-ASODN-1 is used for treating TED. 本发明涉及甲状腺相关眼病的基因疗法领域，具体涉及反义寡核苷酸在制备治疗甲状腺异常引发疾病的药物中的应用。本发明实验结果表明，针对胰岛素样生长因子-1受体IGF-1R的具有特定序列的反义寡核苷酸S-ASODN-1可以有效地降低IGF-1R和抗甲状腺过氧化物酶抗体(TPO-Ab)浓度，提高甲状腺刺激激素(TSH)水平，用于治疗TED。