Application of thymol in preparation of medicine for improving menopausal or sterilization-mediated obesity

• Main Authors: LI HUIXIA, ZHANG YU, LI SHAOCHUAN, SU RENWEI, GUO HAOJUN
• Format: Patent
• Language: Chinese; English
• Published: 11.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of thymol in preparation of a medicine for improving menopausal or sterilization-mediated obesity, and relates to the technical field of biological medicines. Molecular docking analysis shows that the thymol has a site combined with an estrogen receptor (ESR1), so that the thymol can be combined with ESR1 protein to balance an estrogen signal channel, and adverse effects caused by reduction of the estrogen level are made up. Animal experiments prove that thymol can effectively improve menopausal or sterilization-mediated obesity. The invention provides powerful technical support for improving menopausal or sterilization-mediated obesity and developing estrogen substitute drugs, and has a wide market application prospect. 本发明公开了百里香酚在制备改善绝经或绝育介导的肥胖的药物中的应用，涉及生物医药技术领域。本发明通过分子对接分析表明，百里香酚具有与雌激素受体(ESR1)结合的位点，因此百里香酚可以通过与ESR1蛋白结合，来平衡雌激素信号通路，从而弥补雌激素水平降低所导致的不利影响。本发明通过动物实验证明，百里香酚可以有效改善绝经或绝育介导的肥胖。本发明为改善绝经或绝育介导的肥胖以及开发雌激素替代药物提供了有力的技术支持，具有广阔的市场应用前景。