Liposomes containing phosphorylated tau peptides for inducing sustained immune responses

Methods for inducing a sustained immune response against phosphorylated Tau in a human are described. The method comprises administering to the subject an effective amount of a liposome comprising a toll-like receptor 4 agonist, a helper T cell epitope, a lipidated CpG oligonucleotide, and a Tau pho...

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Bibliographic Details
Main Authors PFEIFER, ANDREA, GAPPEN, WOLFGANG, MUHS, ANDREAS
Format Patent
LanguageChinese
English
Published 07.06.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Methods for inducing a sustained immune response against phosphorylated Tau in a human are described. The method comprises administering to the subject an effective amount of a liposome comprising a toll-like receptor 4 agonist, a helper T cell epitope, a lipidated CpG oligonucleotide, and a Tau phosphopeptide presented on the surface of the liposome to thereby obtain a sustained immune response. 描述了用于在人中诱导针对磷酸化Tau的持续免疫反应的方法。该方法包括向受试者施用有效量的包括toll样受体4激动剂、辅助性T细胞表位、脂质化CpG寡核苷酸、和呈递在脂质体的表面上的Tau磷酸肽的脂质体，以由此获得持续免疫反应。
Bibliography:Application Number: CN202280068508