Anti-influenza B hemagglutinin monoclonal antibody and application thereof

• Main Authors: ZHAI YANMEI, SHI MANG, LUO WANYU, CHEN YAOQING, LI YANLING, CAI XIAOYU
• Format: Patent
• Language: Chinese; English
• Published: 07.06.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to the technical field of monoclonal monomers, and particularly discloses an anti-influenza B hemagglutinin monoclonal antibody and application thereof.The anti-influenza B hemagglutinin monoclonal antibody has high specific binding capacity to influenza B virus HA, can neutralize eight influenza B viruses and shows a high hemagglutination inhibition function, and the anti-influenza B hemagglutinin monoclonal antibody can be used for preparing an anti-influenza B hemagglutinin monoclonal antibody. Compared with the currently found antibody, the antibody has a wider neutralization spectrum, has potential application value in detection and treatment of the antibody B, and is expected to become a screening antibody for early diagnosis of influenza B infection serology. 本申请涉及单克隆单体技术领域，具体公开了一种抗乙型流感血凝素单克隆抗体及其应用，本申请的抗乙型流感血凝素单克隆抗体对乙型流感病毒HA具有较强的特异性结合能力，可以中和8种乙型流感病毒，并且表现出强的血凝抑制功能，比目前已发现的抗体的中和谱更广，在检测和治疗乙型抗体具有潜在的应用价值，有望成为乙型流感感染血清学早期诊断的筛选抗体。