Cyclic peptide for treating gastric cancer and pharmaceutical composition thereof

• Main Authors: ZHAO YUN, FANG GEMIN, JIAO SHI, TANG YANG, ZHOU ZHAOCAI, WANG WENJIA
• Format: Patent
• Language: Chinese; English
• Published: 07.06.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of biological medicines, and relates to a macrocyclic polypeptide for treating gastric cancer and a pharmaceutical composition of the macrocyclic polypeptide. In particular relates to a macrocyclic polypeptide molecule obtained by an in-vitro chemical modification method on the basis of a core sequence (VRRIKMLEY) of a B '''regulatory subunit Striatin3 (STRN3) of a protein phosphatase 2A (PP2A) A subunit, and more particularly relates to a topological structure of the cyclic polypeptide and a specific preparation method thereof. Meanwhile, the invention also comprises a mutant and a derivative of the cyclic polypeptide. The macrocyclic polypeptide provided by the invention can be used for further deep development of drugs for inhibiting growth of tumor cells and resisting tumors, so that bioactive lead molecules with high commercial value are provided for cancer treatment. 本发明属于生物医药领域，涉及用于胃癌治疗的大环多肽及其药物组合物。具体是指，在蛋白磷酸酶2A(PP2A)A亚基的B″′调节亚基Striatin3(STRN3)的核心序列(VRRIKMLEY)基础上，通过体外