Extraction method and device of platycodin D and application of platycodin D in preparation of medicine for treating knee osteoarthritis

• Main Authors: NI YINGJIE, WU JIANYUE, QIAO LINGHUI
• Format: Patent
• Language: Chinese; English
• Published: 07.06.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SEPARATION; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS; SUGARS; TRANSPORTING

The invention provides an extraction method and device of platycodin D and application of the platycodin D in preparation of medicines for treating knee osteoarthritis. The extraction method comprises the following steps: 1, putting crushed platycodon grandiflorum and an extraction solvent into an extraction container, adding a proper amount of grinding balls into the extraction container, sealing the extraction container, and putting the extraction container on a vibration generator for vibration extraction; step 2, filtering the extraction mixed solution obtained in the step 1 in an extraction container, and cleaning to obtain an extraction clear solution; step 3, carrying out reduced pressure evaporation and concentration on the extraction clear liquid obtained in the step 2 to obtain platycodin extract; and 4, dissolving the platycodin extract obtained in the step 3 with water, adsorbing and purifying with macroporous resin, eluting, and concentrating to obtain a platycodin D concentrate. Under the cooper