Benzopyran compound and application thereof

• Main Authors: LI KAILI, LI ZHUOHAO, BAI CHUAN, TIAN GUOBAO, ZHONG LANLAN, LIU TAO
• Format: Patent
• Language: Chinese; English
• Published: 04.06.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention belongs to the technical field of biological medicine, and particularly relates to a benzopyran compound and application thereof. According to the present invention, the MCR-1 protein is adopted as the target, the drug design and synthesis means is adopted to obtain the benzopyran compound with characteristics of new structure, high activity and low toxicity, and the activity experiment results show that the benzopyran compound can recover the sensitivity of MCR-1 positive drug-resistant bacteria to polymyxin, can provide the synergistic antibacterial effect when the benzopyran compound is combined with polymyxin, and can be used for preparing the drug-resistant drug-resistant bacteria drug-resistant drug-resistant bacteria drug-resistant drug-resistant bacteria drug-resistant drug-resistant drugs. Acute toxicity experiments show that the compound has the characteristic of low toxicity, and has important value and significance in development of MCR-1 positive drug-resistant bacteria. 本发明属于生物医药技术