Meloxicam self-assembly nano-particle as well as preparation method and application of meloxicam self-assembly nano-particle

• Main Authors: YE XIAOYAN, LI ZHUOYA, CHEN ALI, ZHAO WEIGUO, ZHANG WEI
• Format: Patent
• Language: Chinese; English
• Published: 04.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention provides meloxicam self-assembled nanoparticles as well as a preparation method and application thereof, and relates to the field of pharmaceutical preparations. Comprising the following steps: (1) synthesizing a polypeptide C16-K (PpIX)-CGNKRTR by using ammonia resin solid-phase peptide; dissolving polypeptide with DMSO, and performing ultrasonic treatment to form a polypeptide solution; (2) respectively preparing Mel and PEG2000 into a Mel solution and a PEG solution by using DMSO (Dimethylsulfoxide); the Mel solution and the PEG solution are mixed to obtain a Mel-PEG mixed solution, the Mel-PEG mixed solution is mixed with water for ultrasonic treatment and then mixed with the polypeptide solution for ultrasonic treatment, and an ultrasonic solution is obtained; and finally, dialyzing the ultrasonic solution to obtain the meloxicam self-assembled nanoparticles. The prepared meloxicam self-assembled nanoparticles are stable in particle size, have no cytotoxicity, and can more effectively inhib