Immunogenic LNP compositions and methods thereof

• Main Authors: LI SHILONG, TCHESAROV SERGEY, GUO PENGBO, BHATNAGAR BALAJI SHANKAR, GARCIA, MIGUEL, A, SHI SHUAI, BADKAR, AJAY, V, DARWARI RAJAN
• Format: Patent
• Language: Chinese; English
• Published: 31.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of ribonucleic acid immunogenic compositions and/or vaccines comprising polynucleotide molecules preferably encoding one or more influenza antigens, such as hemagglutinin antigens, where the composition is frozen or lyophilized. 本发明涉及用于制备、制造及治疗性使用核糖核酸免疫原性组合物和/或疫苗的组合物及方法，所述核糖核酸免疫原性组合物和/或疫苗包含优选地编码一种或多种流感抗原，诸如血凝素抗原的多核苷酸分子，其中该组合物经冷冻或冻干。