ATG5 used as coronary atherosclerosis diagnosis biomarker and application thereof

• Main Authors: REN MENGMENG, HE SHU, JIA ENZHI, BIE HENGJIE, LI CHENGCHENG, WANG YANJUN, ZHOU HANXIAO, JIA QIAOWEI, FU YAHONG, CHI BOYU, ZHANG XIN
• Format: Patent
• Language: Chinese; English
• Published: 31.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention discloses application of messenger RNA ATG5 and an expression quantity detection reagent thereof in preparation of a coronary atherosclerosis diagnostic reagent, establishment of a coronary atherosclerosis onset risk column diagram prediction model and application of the coronary atherosclerosis onset risk column diagram prediction model. The invention provides a standard gene suitable for molecular identification of coronary atherosclerosis and a molecular identification method, the gene can effectively distinguish a normal person from a coronary atherosclerosis patient, and the expression level of the gene is applied to diagnosis, so that the coronary heart disease patient can be found in an early stage, the death rate of the coronary heart disease is reduced, and the prognosis of the patient is improved. At present, the main diagnosis method for coronary atherosclerotic heart disease has the risks of high operation danger coefficient, large radiation and the like, and by collecting peripheral