Preparation method and application of covalent organic framework nano material for pyroelectric power therapy

• Main Authors: WANG SHANSHAN, LIU PEINIAN, GAO MENGLU, YOON SU-WON, LI XINGGUANG, XU QIANHE
• Format: Patent
• Language: Chinese; English
• Published: 31.05.2024
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention relates to preparation and application of a covalent organic framework (COF) nano material, and belongs to the field of nano medicine. According to the invention, a covalent organic framework TPAD-COF nano material used for the pyroelectric power therapy of tumors is prepared. The TPAD-COF nano material provided by the invention has excellent photothermal conversion and pyroelectric effects, the temperature is rapidly increased under the irradiation of near-infrared laser, the tumor can be subjected to thermal therapy, and in the process, the temperature change can cause the change of internal polarization of the material and generate pyroelectric charges, so that reactive oxygen species (ROS) substances with cytotoxicity are generated, and the tumor can be treated by virtue of the TPAD-COF nano material. The nano-material provided by the invention can be used for promoting tumor cell apoptosis and inhibiting tumor growth, more importantly, the nano-material provided by the invention can be used