Hyaluronic acid derivative composition, pharmaceutical composition, and hyaluronic acid derivative-drug conjugate composition

The present invention provides: a hyaluronic acid derivative composition; a pharmaceutical composition containing the hyaluronic acid derivative composition as a carrier; and in the hyaluronic acid derivative composition, (A) a hyaluronic acid derivative-drug-bound composition in which one or more d...

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Main Authors YANG SO-YEON, KATSUMATA TORU, YABUUCHI KOHEI, FUKUMOTO KEISUKE, NAKAGAWA YOSHIYUKI
Format Patent
LanguageChinese
English
Published 31.05.2024
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Summary:The present invention provides: a hyaluronic acid derivative composition; a pharmaceutical composition containing the hyaluronic acid derivative composition as a carrier; and in the hyaluronic acid derivative composition, (A) a hyaluronic acid derivative-drug-bound composition in which one or more drugs are bound to a hyaluronic acid derivative; the hyaluronic acid derivative composition contains (A) a hyaluronic acid derivative into which a steroid group is introduced and (B) a polar group-containing compound having at least one functional group selected from the group consisting of a hydroxyl group, a carboxyl group, an amino group, an amide group, a urethane group, a urea group and a mercapto group, wherein the introduction rate of the steroid group with respect to the hyaluronic acid derivative (A) is 0.1% or more but less than 35%. 本发明提供一种透明质酸衍生物组合物、含有该透明质酸衍生物组合物作为载体的药物组合物,以及该透明质酸衍生物组合物中的(A)透明质酸衍生物结合有一个以上的药物的透明质酸衍生物-药物结合组合物;所述透明质酸衍生物组合物含有(A)引入有甾基的透明质酸衍生物和(B)具有选自羟基、羧基、氨基、酰胺基、氨基甲酸酯基、脲基和巯基中的至少一种的官能团的含极性基团化合
Bibliography:Application Number: CN202410237027