Method for recovering intermediate TK-1 from ticagrelor intermediate TK-1 mother liquor

• Main Authors: GAO ZHANWEN, SUN MINGCHUN, ZHANG YANGMIN, ZANG WENCHAO
• Format: Patent
• Language: Chinese; English
• Published: 28.05.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of pharmaceutical production, and particularly relates to a method for recovering an intermediate TK-1 from a ticagrelor intermediate TK-1 mother liquor. The method comprises the following steps: concentrating TK-1 crystallization mother liquor to obtain concentrated mother liquor; stirring and crystallizing the concentrated mother liquor, then carrying out solid-liquid separation, drying the obtained solid product, and dissolving the dried solid product in acetonitrile to obtain a crude product solution; cooling the crude product solution to a first temperature for heat preservation; carrying out solid-liquid separation on the solution subjected to heat preservation to obtain a liquid-phase product; concentrating the liquid-phase product, and dissolving the obtained concentrate in a good solvent to obtain a concentrate solution; adding a poor solvent into the concentrate solution, separating out a solid product, and drying the solid product after solid-liquid sepa