Preparation method of methyl 3-(2-aminoethoxy) propionate or salt thereof

The invention provides a preparation method of 3-(2-aminoethoxy) methyl propionate or salt thereof, which comprises the following steps: taking amino-protected ethanolamine with low price as an initial raw material, carrying out coupling reaction on the amino-protected ethanolamine and methyl propio...

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Bibliographic Details
Main Authors XIANG YONGGANG, ZHU BENQIONG, ZHOU YANMEI, SU WEI, YE CHUANHUI
Format Patent
LanguageChinese
English
Published 28.05.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a preparation method of 3-(2-aminoethoxy) methyl propionate or salt thereof, which comprises the following steps: taking amino-protected ethanolamine with low price as an initial raw material, carrying out coupling reaction on the amino-protected ethanolamine and methyl propiolate to obtain a compound as shown in a formula III, and then sequentially reducing and removing an amino protecting group to obtain a target product. The method is high in yield, safe to operate and suitable for industrial large-scale production. The preparation method disclosed by the invention is low in cost, high in yield, few in steps, safe to operate and very suitable for industrial production. The reaction formula is as follows: # imgabs0 #, wherein R1 is an amino protecting group. 本发明提供了3-(2-氨基乙氧基)丙酸甲酯或其盐的制备方法，该制备方法以价格低廉的胺基保护的乙醇胺为起始原料，与丙炔酸甲酯经偶联反应得到式III化合物，然后依次经还原和脱氨基保护基即可得到目标产物。该方法收率高，操作安全，适合工业化大规模生产。本发明的制备方法，成本低，收率高、步骤少、操作安全，非常适合工业化生产。反应式如下：#imgabs0#其中R1为氨基保护基。
Bibliography:Application Number: CN202410173703