Preparation method of organic hybrid monolithic column and capillary electrophoresis method for separating chiral drug by using organic hybrid monolithic column

The invention provides a preparation method of an organic hybrid monolithic column and a capillary electrophoresis method for separating chiral drugs by using the organic hybrid monolithic column. The preparation method sequentially comprises the following steps: preparing a GMA-alpha-alkenyl-beta-c...

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Bibliographic Details
Main Authors FANG LINLIN, ZHAO LIZHU, GAO NA, FAN GUANGJUN, QI YAN, PENG JINYONG, ZHANG YAOWEN
Format Patent
LanguageChinese
English
Published 28.05.2024
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:The invention provides a preparation method of an organic hybrid monolithic column and a capillary electrophoresis method for separating chiral drugs by using the organic hybrid monolithic column. The preparation method sequentially comprises the following steps: preparing a GMA-alpha-alkenyl-beta-cyclodextrin monomer, preparing hydrolysate and carrying out condensation polymerization reaction; in the step of condensation polymerization, 40 to 80 mg of GMA-alpha-alkenyl-beta-cyclodextrin monomer, 20 [mu] L of water, 21 [mu] L of N, N-dimethylformamide, 1.2 to 2.2 mg of cetyltrimethylammonium bromide (CTAB) and 1 mg of azodiisobutyronitrile (AIBN) are mixed, 0.5 mL of hydrolysate is added, and the mixture is uniformly mixed; after vortex ultrasonic treatment is carried out for 10 seconds, the mixture is poured into a capillary tube with the inner diameter being 25-75 microns and the length being 30-35 cm, after the two ends of the capillary tube are blocked, the capillary tube is placed under the conditions th
Bibliography:Application Number: CN202410220674