Water-soluble O-acetylated chitosan oligosaccharide as well as preparation method and application thereof

• Main Authors: XING RONG'E, ZHU SIQI, WANG XIN, LI PENGCHENG, LIU YUANJIE, YANG HAOYUE, LIU SONG, GE XIANGYUN, LI KECHENG
• Format: Patent
• Language: Chinese; English
• Published: 24.05.2024
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention discloses a water-soluble O-acetylated chitosan oligosaccharide as well as a preparation method and application thereof, and the preparation method comprises the following steps: carrying out acetylation reaction on chitosan oligosaccharide to obtain peracetylated chitosan oligosaccharide; the preparation method comprises the following steps: adding peracetylated chitosan oligosaccharide into ammonia water with the mass fraction of 10%, and stirring to react for 10-60 minutes; and filtering the reaction liquid, and freeze-drying the filtrate to obtain the O-acetylated chitosan oligosaccharide product. The preparation method disclosed by the invention is simple in step, the product is good in water solubility and has strong anti-inflammatory activity, a new thought is provided for high-value utilization of the marine chitin polysaccharide, and the preparation method also has important significance for promoting innovative development of novel marine drugs. 本发明公开了一种水溶性O-乙酰化几丁寡糖及其制备方法和应用，制备方法包括如下步骤