Application of pulsatilla saponin B4 derivative in preparation of medicine for preventing and treating psoriasis

• Main Authors: XU QIONGMING, LIU YANLI, DU YEXIN
• Format: Patent
• Language: Chinese; English
• Published: 24.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a biological medicine technology, in particular to application of an anemoside B4 derivative in preparation of a medicine for treating or preventing psoriasis. When the pulsatilla saponin B4 is used for treating psoriasis, the effect of the pulsatilla saponin B4 needs to be The pulsatilla saponin B4 is used as a lead compound, a series of structural modification and transformation are carried out, and the drug activity and bioavailability are improved unexpectedly. Animal experiment results show that the pulsatilla saponin B4 derivative has a protective effect on skin lesion change of psoriasis, and the effect is better than that of glucocorticoid drugs. Particularly, the pulsatilla saponin B4 derivative disclosed by the invention unexpectedly achieves a technical progress which is obviously better than that of pulsatilla saponin B4. 本发明涉及生物医药技术，尤其涉及一种白头翁皂苷B4衍生物在制备治疗或预防银屑病的药物中的应用。以白头翁皂苷B4治疗银屑病，其作用还需改善。本发明以白头翁皂苷B4为先导化合物，进行一系列结构修饰和改造，出乎意料的提高药物活性和生物利用度。动物实验结果显示白头翁皂苷B4衍生物对银屑病皮损改变具有保护作用，且效