Pyrazole-3-ketone derivative as well as preparation method and application thereof

The invention discloses a pyrazole-3-ketone derivative as well as a preparation method and application thereof, belongs to the technical field of medicines, and particularly relates to the pyrazole-3-ketone derivative shown in a general formula I, pharmaceutically acceptable salt of the pyrazole-3-k...

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Main Authors ZHAO SHAN, HOU LINGHUI, LIU DAN, ZHANG ZHENWEI, ZHAO LINXIANG, PEI JIYING, HUANG MIN, JING YONGKUI
Format Patent
LanguageChinese
English
Published 21.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a pyrazole-3-ketone derivative as well as a preparation method and application thereof, belongs to the technical field of medicines, and particularly relates to the pyrazole-3-ketone derivative shown in a general formula I, pharmaceutically acceptable salt of the pyrazole-3-ketone derivative, a preparation method of the derivative and a pharmaceutical composition taking the derivative as an active component. And to the use of a medicament for the treatment and/or prevention of various cancers. According to the pyrazole-3-ketone derivative disclosed by the invention, the apoptosis of tumor cells can be directly induced by activating Bax, promoting mitochondrial translocation and oligomerization of Bax, causing a permeabilization effect of a mitochondrial outer membrane, releasing mitochondrial proteins such as cytochrome c into cytoplasm and activating caspase cascade reaction. Therefore, the compound can be used for preparing medicines for treating diseases related to Bcl-2 protein fam
Bibliography:Application Number: CN202211455030