Ferulate analogue, preparation method and application thereof

The invention provides a ferulate analogue as well as a preparation method and application thereof, the structural general formula of the disclosed compound is as shown in formula (1), R1 is selected from H,-OH or OCH3, R2 is selected from 2-methylene-3, 5, 6-trimethyl ligustrazine, n is a carbon ch...

Full description

Saved in:
Bibliographic Details
Main Authors BAI YUJUN, SUN BAO, JIA PU, WANG PING'AN, BAI YAJUN, ZHAO YE, SUN YING, ZHANG SHENGYONG, MA RUOXIN, ZHENG XIAOHUI, XIA ZHAODI
Format Patent
LanguageChinese
English
Published 17.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides a ferulate analogue as well as a preparation method and application thereof, the structural general formula of the disclosed compound is as shown in formula (1), R1 is selected from H,-OH or OCH3, R2 is selected from 2-methylene-3, 5, 6-trimethyl ligustrazine, n is a carbon chain and is selected from 2, 3, 4, 5, 6, 7, 8, 9 or 10, and n is selected from 2, 3, 4, 5, 6, 7, 8, 9 or 10. R < 3 > is selected from dimethylamino, diethylamino, pyrrolidinyl, piperidinyl, piperazinyl, N-ethyl piperazinyl, 4-benzyl piperidinyl, guanidyl or diisopropylamine. The invention also provides a preparation method of the derivative and application of the derivative in treating neurodegenerative diseases, improving vascular dementia and memory impairment and cognition caused by dementia, and improving cerebral ischemia and brain nerve injury and antithrombotic activity. # imgabs0 # 本发明提供了一类阿魏酸酯类似物、制备方法及其应用，所公开的化合物结构通式如式(1)所示，其中，R1选自H、-OH或OCH3，R2选自2-亚甲基-3,5,6-三甲基川芎嗪，n为碳链，选自2、3、4、5、6、7、8、9或10；R3选自二甲胺基、二乙胺基、四氢吡
Bibliography:Application Number: CN202410045128