Preparation method of high-stability aminomethylbenzoic acid injection

A preparation method of a high-stability aminomethylbenzoic acid injection belongs to the technical field of medicines and comprises preparation of p-iodobenzylbenzoic acid and preparation of aminomethylbenzoic acid. According to the method, in the preparation process of p-iodobenzylbenzoic acid, ed...

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Bibliographic Details
Main Author ZHAO YEQI
Format Patent
LanguageChinese
English
Published 17.05.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A preparation method of a high-stability aminomethylbenzoic acid injection belongs to the technical field of medicines and comprises preparation of p-iodobenzylbenzoic acid and preparation of aminomethylbenzoic acid. According to the method, in the preparation process of p-iodobenzylbenzoic acid, edetate disodium is added to be matched with potassium permanganate to reduce the adding proportion step by step, impurities in a reaction system can be well removed, meanwhile, the reaction system cannot be affected, a large number of impurities cannot be introduced in the later stage of the reaction, and the purity of p-iodobenzylbenzoic acid is improved; in the preparation process of aminomethylbenzoic acid, the added PAM anionic flocculant can be further complexed with metal ion impurities to generate solid precipitates, the solid precipitates are re-suspended in hot water, solid impurities can be well removed through hot filtration, filtrate is purified, high-purity aminomethylbenzoic acid is separated out at a
Bibliography:Application Number: CN202410179969