Uridine-modified ruthenium (II) complex, preparation method thereof and application of uridine-modified ruthenium (II) complex as photodynamic therapy photosensitizer

• Main Authors: MUI MAN KIT, WU QIONG
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention provides a uridine-modified ruthenium (II) complex as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The uridine-modified ruthenium (II) complex RdU is synthesized through a click chemistry reaction for the first time, the RdU can be specifically combined with LIMP-2, generation of a large number of ROS is promoted under illumination, tumor cells are induced to generate ferroptosis, growth of the tumor cells is inhibited, and the uridine-modified ruthenium (II) complex RdU has a good photodynamic therapy effect on tumors and has good application prospects. The compound is expected to be developed into a potential photodynamic therapy photosensitizer for LIMP-2 targeted therapy of tumors. 本发明提供了一种尿苷修饰的钌(II)配合物及其制备方法和应用，属于药物化学技术领域。本发明首次利用"点击化学"反应合成尿苷修饰的钌(II)配合物RdU，RdU可以与LIMP-2特异性结合，光照下促进大量ROS产生，诱导肿瘤细胞发生铁死亡，抑制肿瘤细胞的生长，对肿瘤具有良好的光动力治疗效果，有望被开发为LIMP-2靶向治疗肿瘤的潜在光动力治疗光敏剂。