Sulfonyl bridged physalin-containing compound small physalin S as well as preparation method and application of sulfinyl bridged physalin-containing compound small physalin S
The invention provides a thionyl bridge-containing physalin compound small physalin S as well as a preparation method and application thereof, a new physalin compound small physalin S separated and extracted from small physalis, and the molecular structure of the small physalin S is # imgabs0 #. The...
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Main Authors | , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
14.05.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The invention provides a thionyl bridge-containing physalin compound small physalin S as well as a preparation method and application thereof, a new physalin compound small physalin S separated and extracted from small physalis, and the molecular structure of the small physalin S is # imgabs0 #. The small physalin S disclosed by the invention has anti-inflammatory activity, can be used for remarkably improving the activity of PC12 cells suffering from hypoxia reperfusion injury, and can be used for preparing anti-inflammatory drugs for treating hypoxia reperfusion injury. The action mechanism is related to the inhibition of expression of NLRP3 inflammasome and pyroptosis-related protein and the inhibition of release of inflammatory factors, so that the small physalin S can be popularized as a medicine for treating ischemic brain injury, and has good development and application prospects.
本发明提供一种含亚硫酰桥酸浆苦素类化合物小酸浆素S及其制备方法与应用,从小酸浆中分离提取到的酸浆苦素类新化合物小酸浆素S,其具有I的分子结构:#imgabs0#本发明的小酸浆素S具有抗炎活性、可以显著改善缺氧再灌注损伤的PC12细胞的活力,其作用 |
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Bibliography: | Application Number: CN202311839641 |