Fluorescence enhanced probe for detecting GSH (glutathione) and ATP (adenosine triphosphate) as well as preparation method and application thereof

• Main Authors: YU FABIAO, DOU KUN, ZHAO GUILING, WANG YONGHAI
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2024
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PHYSICS; POLISHES; TESTING

The invention discloses a fluorescence enhanced probe for detecting GSH (glutathione) and ATP (adenosine triphosphate) as well as a preparation method and application of the fluorescence enhanced probe, and relates to the technical field of fluorescence probes. The fluorescence enhanced probe is named as M901, and has a structural formula as shown in the following formula (I): # imgabs0 # formula (I). Meanwhile, the invention further discloses a method for preparing the fluorescent probe based on the modified rhodamine and naphthalimide double fluorophores and application of the fluorescent probe to detection of glutathione (GSH) and adenosine triphosphate (ATP). The preparation method is simple and easy to implement and low in cost, and the prepared probe is stable in structure. Under mild conditions, the probe can be applied to high-sensitivity, high-selectivity, rapid and visual detection of GSH and ATP. In addition, the probe has been successfully applied to simultaneous detection of GSH and ATP in biolog