Application of targeting sphingomyelin receptor S1PR1 PET probe in preparation of Alzheimer disease curative effect monitoring product

• Main Authors: LI SHENGQIAO, WANG LU, JIN HONGJUN, ZENG QI, BI LEI, HOU YUYI, SHEN PEINING, YE PEIZHEN, LIU YONGSHAN
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention discloses an application of a targeting sphingomyelin receptor S1PR1PET probe in preparation of a curative effect monitoring product for treatment of Alzheimer's disease. The target sphingomyelin receptor S1PR1PET probe is a [18F] TZ4877 probe, the target sphingomyelin receptor S1PR1PET probe is used for evaluating the curative effect of improving the Alzheimer's disease through traditional Chinese medicine acupuncture and moxibustion, verification shows that the target sphingomyelin receptor S1PR1PET probe is more sensitive and rapid compared with an existing probe, the curative effect of the Alzheimer's disease can be more sensitively and objectively evaluated from the molecular level, and the target sphingomyelin receptor S1PR1PET probe has the advantages that the target sphingomyelin receptor The method has a great application value in effective objective evaluation of various Alzheimer disease anti-inflammatory therapies. 本发明公开了靶向鞘磷脂受体S1PR1PET探针在制备阿尔茨海默病治疗的疗效监测产品中的应用。所述靶向鞘磷脂受体S1PR1PET探针为[18