Acid-responsive self-assembled nano-material capable of targeting mitochondria and application of nano-material in preparation of antitumor drugs

• Main Authors: LYU YULIN, WANG LU, YANG GUANG, XU WANHAI, WANG YUTING
• Format: Patent
• Language: Chinese; English
• Published: 14.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an acid-responsive self-assembled nano-material capable of targeting mitochondria and application of the acid-responsive self-assembled nano-material in preparation of antitumor drugs, and belongs to the technical field of biological medicines. The acid response self-assembly nano material capable of targeting the mitochondria comprises a targeting sequence capable of targeting the mitochondria, a peptide fragment capable of being self-assembled to form a nano fibrous structure, an acid response group and a sound-sensitive agent. According to the acid response self-assembly nano material capable of targeting mitochondria, the intracellular transmission efficiency of the nano material can be improved by destroying lysosomes, the mitochondria is damaged in a targeting manner, the occurrence of mitochondrial autophagy is blocked, and the tumor development is inhibited; the invention is the first report that the self-assembly structure is combined with the sonodynamic therapy to inhibit th