Acid-responsive self-assembled nano-material capable of targeting mitochondria and application of nano-material in preparation of antitumor drugs
The invention discloses an acid-responsive self-assembled nano-material capable of targeting mitochondria and application of the acid-responsive self-assembled nano-material in preparation of antitumor drugs, and belongs to the technical field of biological medicines. The acid response self-assembly...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
14.05.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses an acid-responsive self-assembled nano-material capable of targeting mitochondria and application of the acid-responsive self-assembled nano-material in preparation of antitumor drugs, and belongs to the technical field of biological medicines. The acid response self-assembly nano material capable of targeting the mitochondria comprises a targeting sequence capable of targeting the mitochondria, a peptide fragment capable of being self-assembled to form a nano fibrous structure, an acid response group and a sound-sensitive agent. According to the acid response self-assembly nano material capable of targeting mitochondria, the intracellular transmission efficiency of the nano material can be improved by destroying lysosomes, the mitochondria is damaged in a targeting manner, the occurrence of mitochondrial autophagy is blocked, and the tumor development is inhibited; the invention is the first report that the self-assembly structure is combined with the sonodynamic therapy to inhibit th |
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Bibliography: | Application Number: CN202410180045 |