Preparation method of tenofovir alafenamide fumarate impurity
The invention discloses a preparation method of a tenofovir alafenamide fumarate impurity, which comprises the following steps: preparing a compound 1, a compound 2, a compound 3, a compound 4, a compound 5 and a compound 6, specifically, condensing PMPA and HPA to obtain the compound 1; respectivel...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
10.05.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a preparation method of a tenofovir alafenamide fumarate impurity, which comprises the following steps: preparing a compound 1, a compound 2, a compound 3, a compound 4, a compound 5 and a compound 6, specifically, condensing PMPA and HPA to obtain the compound 1; respectively reacting the compound 1 with phenol and L-alanine isopropyl ester under chloro and alkaline conditions to obtain a compound 2 and a compound 3; the preparation method comprises the following steps: condensing PMPA monophenyl ester with L-alanine benzyl ester through chlorination under an alkaline condition, and then reducing and hydrogenating by taking methanol as a solvent to obtain a compound 4; the preparation method comprises the following steps: respectively reacting PMPA monophenyl ester with L-alanine methyl ester and L-alanine ethyl ester through chlorination under an alkaline condition to obtain a compound 5 and a compound 6; the synthesis method disclosed by the invention has the advantages of easily av |
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Bibliography: | Application Number: CN202311868800 |