Application of phospholipase PLA2G7 in promoting remodeling and maturation of blood vessels

• Main Authors: CAI XIAODONG, WANG HONGKUI, GU XIAOSONG, QIAN TIANMEI, LU PANJIAN, CHENG XIYANG, XUE CHENGBIN, FENG SHUYUE
• Format: Patent
• Language: Chinese; English
• Published: 10.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses an application of phospholipase PLA2G7 in promoting remodeling and maturation of blood vessels. Experiments prove that PLA2G7 can promote remodeling and maturation of blood vessels by inhibiting migration and tube formation of vascular endothelial cells under a proper high-concentration dosage, and meanwhile, proliferation and apoptosis behaviors of the vascular endothelial cells are not influenced; the PLA2G7 recombinant protein or a sustained-release system prepared from the PLA2G7 recombinant protein and a sustained-release material carrier can be applied to the fields of peripheral nerve regeneration and the like through the ability of promoting vascular remodeling and maturation. The invention discloses the first phospholipase with definite effects of inhibiting angiogenesis and promoting remodeling and maturation of blood vessels, and a target spot is provided for construction of tissue engineering tissue organs, organoids and the like for promoting repair and regeneration by pro