Production of hepatocytes

The present invention relates to a method of producing hepatocytes, the method comprising introducing a group of transcription factors consisting of HNF1A, HNF6, FOXA3, RORc and ERa into a population of iPSCs, and culturing the population, thereby producing hepatocytes. Methods of producing hepatocy...

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Bibliographic Details
Main Authors DE COSTA THOMAS, RODRIGO, A, VARRIER LUDOVIC
Format Patent
LanguageChinese
English
Published 07.05.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to a method of producing hepatocytes, the method comprising introducing a group of transcription factors consisting of HNF1A, HNF6, FOXA3, RORc and ERa into a population of iPSCs, and culturing the population, thereby producing hepatocytes. Methods of producing hepatocytes, hepatocytes produced by these methods, and uses and uses of these hepatocytes are provided. 本发明涉及产生肝细胞的方法，该方法包括将一组由HNF1A、HNF6、FOXA3、RORc和ERα组成的转录因子引入iPSC群体，以及培养该群体，从而产生肝细胞。提供了产生肝细胞的方法、通过这些方法产生的肝细胞以及这些肝细胞的用途和应用。
Bibliography:Application Number: CN202280061355