Biodegradable tissue replacement implants and uses thereof

• Main Authors: BHATTI KAPIL, MANISHKIS, ALEXANDER
• Format: Patent
• Language: Chinese; English
• Published: 07.05.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

Tissue replacement implants are disclosed that include polarized retinal pigment epithelial cells on a poly (lactic-co-glycolic acid) (PLGA) scaffold wherein the PLGA scaffold has a thickness of 20 to 30 microns, a DL-lactide/glycolide ratio of about 1: 1, an average pore size of less than about 1 micron, and a fiber diameter of about 150 to about 650 nm. Also disclosed are methods of treating a subject having a retinal degenerative disease, retinal or retinal pigment epithelium dysfunction, retinal degeneration, retinal impairment, or retinal pigment epithelium deficiency. The methods include topically administering the tissue replacement implant to an eye of a subject. In further embodiments, a method for producing the tissue replacement implant is disclosed. 公开了组织置换植入物，该组织置换植入物包括在聚(乳酸-共-乙醇酸)(PLGA)支架上的极化的视网膜色素上皮细胞，其中该PLGA支架的厚度为20-30微米，具有约1:1的DL-丙交酯/乙交酯比例，平均孔径小于约1微米，并且纤维直径为约150至约650nm。还公开了治疗患有视网膜变性疾病、视网膜或视网膜色素上皮功能障碍、视网膜退化、视网膜损害、或视网膜色素上皮缺失的受试者的方法。这些方法包括向受试者的眼睛局部施用该组织置换植入物。在进一步的实施方式中，公开了用于产生该组织置换植入物的方法。