Lipid-hydrogel composite drug delivery system and preparation method thereof

• Main Authors: YANG ZHENGMENG, TORTORELLA, MICHELE, HOU NAN, FENG LU, LI GANG
• Format: Patent
• Language: Chinese; English
• Published: 07.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to the technical field of tissue engineering, and provides a lipid-hydrogel composite drug delivery system and a preparation method thereof. The lipid-hydrogel composite drug delivery system comprises a composite liposome and hydrogel loaded with the composite liposome, wherein the composite liposome comprises a cell and tissue regeneration promoting functional agent serving as an active ingredient and a liposome loaded with the cell and tissue regeneration promoting functional agent, and the hydrogel is dynamic hyaluronic acid hydrogel. According to the lipid-hydrogel composite drug delivery system provided by the invention, the hydrogel loaded with the composite liposome has a stable structure and good biocompatibility, so that the hydrogel is suitable for transportation, and the liposome loaded with the functional agent for promoting cell and tissue regeneration can be captured in a hydrogel network in a uniformly dispersed state; the structural stability of the liposome can be enhanc