Electrochemical iodination of N, N '-(2, 3-dihydroxypropyl)-5-hydroxy-1, 3-benzenedicarboxamide

• Main Authors: MINGUZZI, ALESSANDRO, SOLTI LUCA, VERTOVA, ALESSANDRA, LATTUADA LUCIANO, UGGERI FULVIO, GIOVENZANA GIOVANNI BATTISTA, CAVALLOTTI, CLAUDIO, MORELLI CRISTIANO
• Format: Patent
• Language: Chinese; English
• Published: 03.05.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTIONOF COMPOUNDS OR NON-METALS; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a method for preparing an iodinated X-ray contrast agent. More specifically, it relates to a process for the preparation of N, N '-bis-(2, 3-dihydroxypropyl)-5-hydroxy-2, 4, 6-triiodo-1, 3-phthalimide (I) by electrochemical iodination of N, N'-(2, 3-dihydroxypropyl)-5-hydroxy-1, 3-phthalimide (II) with molecular iodine (I2) generated electrochemically in situ from a source of iodide ions (I-). The iodide ion (I-) is obtained by dissolving hydrogen iodide (HI) or an alkali metal iodide in a reaction medium, or is generated during the reaction of N, N '-(2, 3-dihydroxypropyl)-5-hydroxy-1, 3-benzene dicarboxamide and I2. The invention also relates to the use of an intermediate compound of formula (I) obtained by the above electrochemical iodination of compound (II) for the preparation of N, N '-bis [2, 3-dihydroxypropyl]-5 (hydroxyacetyl) methylamino]-2, 4, 6-triiodo-1, 3-phthalimide (iomeprol). 本发明涉及一种用于制备碘化X-射线造影剂的方法。更具体地，其涉及一种用于通过用分子碘(I2)电化学碘化N,N'-(2,3-二羟基丙基)-5-羟基-1,3-苯二甲酰胺(II)来制备N,N'