UPAR-targeted CAR-T cell and application thereof

• Main Authors: ROMSER PETER, LOWE STEPHEN W, VEGAS, CARLOS, A
• Format: Patent
• Language: Chinese; English
• Published: 03.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present disclosure provides methods for treating Covid-associated pulmonary fibrosis or rectal cancer in a subject. Also disclosed herein are methods for delaying or reducing the effects of aging in a subject in need thereof. Methods of the technology of the invention comprise administering to a subject an effective amount of an engineered immune cell that expresses a uPAR-specific chimeric antigen receptor. 本公开提供了用于在受试者中治疗Covid相关的肺纤维化或直肠癌的方法。本文还公开了用于在有此需要的受试者中延迟或减轻衰老的影响的方法。本发明技术的方法包含向受试者施用有效量的表达uPAR特异性嵌合抗原受体的工程改造的免疫细胞。