Bupivacaine multivesicular liposome preparation and application thereof

• Main Authors: SIMONIAN ALYSSA R, GARCIA, LOUIS, D, DAVIS PAIGE N, GRIGSBY, JOHN, J., JR, LEVI, ILAN, LYON, DAMON, A, LOS KATHLEEN D. A, ADKANI, SOROS, M, KURZ STEPHANIE M
• Format: Patent
• Language: Chinese; English
• Published: 03.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Some embodiments of the present application relate to multivesicular liposome formulations comprising bupivacaine at high concentrations for the purpose of preventing, treating or ameliorating pain, such as post-operative pain, over an extended period of time. Also provided are methods of making and administering bupivacaine encapsulated multivesicular liposome formulations (BUP-MVL) and their use as medicaments. 本申请的一些实施方式涉及多囊脂质体制剂，所述多囊脂质体制剂包含高浓度的布比卡因以用于在延长的时间段内预防、治疗或改善疼痛，例如术后疼痛的目的。还提供了布比卡因包封多囊脂质体制剂(BUP-MVL)的制造和施用方法及其作为药物的用途。