New bone material alternative synthesis formula, preparation method and use method

• Main Authors: LAI JINGRAN, HUANG QILIN, HUANG ZHONGLIAN, XIN WEIXIAN, HE GUILING
• Format: Patent
• Language: Chinese; English
• Published: 03.05.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention provides a novel bone material substitute synthesis formula, a preparation method and a use method. The bone material composite particle comprises a copolymer of hydroxyethyl methyl methacrylate (HEMA) and methyl methacrylate (MMA), and calcium phosphate coated on the surface of the copolymer. The synthesized bone substitute material has more excellent biocompatibility, osteoconductivity, rheological property, mechanical property and mechanical property. The bone material disclosed by the invention can be used in the fields of maxillofacial surgery, plastic surgery, spine surgery, osteonecrosis, osteoporosis and the like, is beneficial to helping patients to recover, and greatly shortens the hospitalization time. 本发明提供了一种新的骨材料替代合成配方、制备方法和使用方法。本发明的骨材料复合物颗粒包括羟乙基甲基丙烯酸甲酯(HEMA)和甲基丙烯酸甲酯(MMA)的共聚物，以及，包覆在所述共聚物表面上的磷酸钙。合成的骨替代材料有更优越的生物相容性、骨传导性、流变性能、以及力学性能和机械性能。本发明的骨材料可用于颌面外科、整形外科、脊柱外科、骨坏死、骨质疏松等领域，有助于帮助病人复原，大大缩短住院时间。