C3b receptor targeting drug delivery system, preparation method and application

• Main Authors: ZHAO JIARUI, WU JINGYUAN, REN SHENGNAN, NIU LIMAN, CHEN FANGFANG, WEN CHULING, JIANG SHAN, WU WEN, REN PING, XU YIKE, WU QIONG, LIU QIHUI, LI YUANYUAN, CUI JIAQI
• Format: Patent
• Language: Chinese; English
• Published: 03.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of drug delivery, and particularly provides a drug delivery system targeting a C3b receptor, a preparation method and application, a drug is combined to IONP-COOH-20, the drug-loaded IONP-COOH-20 and healthy human plasma are co-incubated, the drug-loaded IONP-COOH-20 interacts with part of protein molecules in the healthy human plasma, the surface of the drug-loaded IONP-COOH-20 is coated with a protein crown, and the drug-loaded IONP-COOH-20 and the healthy human plasma are co-incubated. Part of protein molecules are complement protein C3b, so that the efficiency and the specificity of a drug entering tumor cells are improved, the effect of killing the tumor cells by the drug is improved, and meanwhile, the toxic and side effects on normal tissue cells are reduced. 本发明属于药物递送领域，具体提供靶向C3b受体的药物递送系统、制备方法及用途，将药物结合到IONP-COOH-20上，载药后的IONP-COOH-20与健康人血浆共孵育，载药后的IONP-COOH-20与健康人血浆中的部分蛋白分子相互作用使其表面包被上蛋白冠，再通过离心重悬后得到药物递送系统，所述的部分蛋白分子为补体蛋白C3b，增加药物进入肿瘤细胞的效率及特异性，提高药物杀伤肿瘤细胞的效果，同时减小对正常组织细胞的毒副作