HER2 mutation inhibitors

• Main Authors: HICKEN ERIK JAMES, NEWHOUSE BRAD J, SCHELP RICHARD A, ROSEN RICHARD Z, ELLIS BRIAN D, PAJIC, STEPHEN, P, LAIRD, ERIC, R, LAZZARA NICHOLAS CHARLES
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of formula (I): # imgabs0 # and enantiomers thereof wherein A, L2, R1, R2, R3, R4 and n are as defined herein, as well as pharmaceutically acceptable salts of the formula (I) and the enantiomers. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and methods and uses of such compounds, salts and compositions for treating abnormal cell growth, including cancer, in a subject in need thereof. 本发明是关于式(I)化合物：#imgabs0#及其对映异构体，以及式(I)及该对映异构体的药学上可接受的盐，其中A、L2、R1、R2、R3、R4及n如本文所定义。本发明进一步是关于包含此类化合物及盐的药物组合物，以及此类化合物、盐及组合物用于治疗有需要受试者的异常细胞生长(包括癌症)的方法及用途。