AQP1 gene therapy for preventing radiation-induced saliva hypofunction

• Main Authors: HOFFMAN MATTHEW P, CIOLINI JOHN A
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Prior to treatment of the salivary gland with ionizing radiation (IR), administration of aquapoprotein-1 (AQP1) complementary deoxyribonucleic acid (cDNA) to the salivary gland prevents subsequent IR-induced loss of function. AQP1 (e.g., human AQP1; hAQP1), which can mitigate or prevent IR-induced saliva hypofunction, resulting in an increase in saliva output. 在用电离辐射(IR)治疗唾液腺之前，向唾液腺施用水通道蛋白-1(AQP1)互补脱氧核糖核酸(cDNA)防止随后的IR诱导的功能丧失。在IR治疗(例如，在患有头颈癌的患者中)之前施用AQP1(例如，人AQP1；hAQP1)，可以减轻或预防IR诱导的唾液功能减退，导致唾液输出增加。