AQP1 gene therapy for preventing radiation-induced saliva hypofunction
Prior to treatment of the salivary gland with ionizing radiation (IR), administration of aquapoprotein-1 (AQP1) complementary deoxyribonucleic acid (cDNA) to the salivary gland prevents subsequent IR-induced loss of function. AQP1 (e.g., human AQP1; hAQP1), which can mitigate or prevent IR-induced s...
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Main Authors | , |
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Format | Patent |
Language | Chinese English |
Published |
26.04.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Prior to treatment of the salivary gland with ionizing radiation (IR), administration of aquapoprotein-1 (AQP1) complementary deoxyribonucleic acid (cDNA) to the salivary gland prevents subsequent IR-induced loss of function. AQP1 (e.g., human AQP1; hAQP1), which can mitigate or prevent IR-induced saliva hypofunction, resulting in an increase in saliva output.
在用电离辐射(IR)治疗唾液腺之前,向唾液腺施用水通道蛋白-1(AQP1)互补脱氧核糖核酸(cDNA)防止随后的IR诱导的功能丧失。在IR治疗(例如,在患有头颈癌的患者中)之前施用AQP1(例如,人AQP1;hAQP1),可以减轻或预防IR诱导的唾液功能减退,导致唾液输出增加。 |
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Bibliography: | Application Number: CN202280058429 |