Application of CD81 gene as glioblastoma molecular marker

• Main Authors: SHAO CHUNLIN, CHEN QIANPING, PAN YAN, ZHANG JIANGHONG, ZHENG WANG, ZENG LIANG
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides application of a CD81 gene as a molecular marker for radiosensitivity and immunosuppression of glioblastoma, and belongs to the technical field of biological medicines. The expression of the CD81 gene in glioblastoma radiation-tolerant strain cells is obviously higher than that in glioblastoma radiation-sensitive strain cells, the radiosensitivity of glioblastoma can be remarkably enhanced by inhibiting the expression level of the CD81 gene, and meanwhile, the tumor lethality of effector T cells in a tumor microenvironment can be enhanced. 本发明提供了CD81基因在作为胶质母细胞瘤辐射敏感性及免疫抑制性的分子标志物中的应用，属于生物医药技术领域。本发明所述的CD81基因在胶质母细胞瘤辐射耐受株细胞中的表达明显高于胶质母细胞瘤辐射敏感株细胞中的表达，通过抑制CD81基因的表达水平可以显著增强胶质母细胞瘤的放射敏感性，同时可以增强肿瘤微环境中效应T细胞的肿瘤杀伤力。