Green preparation method for synthesizing asymmetric thioether and derivative thereof by taking benzenesulfonyl hydrazide compound as sulfur source

• Main Authors: SUN YONGQI, JIA XUEQIN, LU YIHENG, LIU JITENG, FU WENQIAN
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of synthesis of asymmetric thioether and derivatives thereof, and discloses a green preparation method for synthesizing asymmetric thioether and derivatives thereof by taking a benzenesulfonyl hydrazine compound as a sulfur source. Zeolite-based metal is used for catalysis, benzenesulfonyl hydrazide and derivatives thereof and iodobenzene and derivatives thereof are used as raw materials, non-para-aryl thioether and derivatives thereof are synthesized under mild reaction conditions, benzenesulfonyl hydrazide which is low in price and easy to obtain is used as a sulfur source and a reducing agent, construction of a C-S bond is achieved, Beta zeolite is used as an adopted carrier, and the method is suitable for industrial production. According to the present invention, the catalysis conditions can achieve the high conversion rate and the excellent product selectivity, the substrate range is wide, and the functional group tolerance is high. 本发明属于非对称硫醚及其衍生物合成技术领域，公开了一种