Chitosan quaternary ammonium salt injectable hydrogel composite material as well as preparation method and application thereof

• Main Authors: REN KEFENG, ZHANG JIEXUAN, JI JIAN
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The invention discloses a chitosan quaternary ammonium salt injectable hydrogel composite material as well as a preparation method and application thereof. Comprising the following steps: step 1, carrying out grafting reaction on hyaluronic acid and methacrylic anhydride to obtain hyaluronic acid grafted with methacrylic anhydride; step 2, reacting chitosan with 2, 3-epoxypropyl trimethyl ammonium chloride at 70-85 DEG C, and purifying and drying a product to obtain chitosan quaternary ammonium salt; and step 3, mixing the methacrylic anhydride grafted hyaluronic acid and chitosan quaternary ammonium salt in water, adding phenyl (2, 4, 6-trimethylbenzoyl) lithium phosphate, and performing crosslinking under ultraviolet light to obtain the chitosan quaternary ammonium salt injectable hydrogel composite material. The hydrogel has excellent antibacterial property, biocompatibility, good dissolvability and mechanical property, can be used for wounds in different shapes to achieve a bactericidal effect, and also h