Chitosan quaternary ammonium salt injectable hydrogel composite material as well as preparation method and application thereof
The invention discloses a chitosan quaternary ammonium salt injectable hydrogel composite material as well as a preparation method and application thereof. Comprising the following steps: step 1, carrying out grafting reaction on hyaluronic acid and methacrylic anhydride to obtain hyaluronic acid gr...
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Main Authors | , , |
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Format | Patent |
Language | Chinese English |
Published |
26.04.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a chitosan quaternary ammonium salt injectable hydrogel composite material as well as a preparation method and application thereof. Comprising the following steps: step 1, carrying out grafting reaction on hyaluronic acid and methacrylic anhydride to obtain hyaluronic acid grafted with methacrylic anhydride; step 2, reacting chitosan with 2, 3-epoxypropyl trimethyl ammonium chloride at 70-85 DEG C, and purifying and drying a product to obtain chitosan quaternary ammonium salt; and step 3, mixing the methacrylic anhydride grafted hyaluronic acid and chitosan quaternary ammonium salt in water, adding phenyl (2, 4, 6-trimethylbenzoyl) lithium phosphate, and performing crosslinking under ultraviolet light to obtain the chitosan quaternary ammonium salt injectable hydrogel composite material. The hydrogel has excellent antibacterial property, biocompatibility, good dissolvability and mechanical property, can be used for wounds in different shapes to achieve a bactericidal effect, and also h |
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Bibliography: | Application Number: CN202311847954 |